Storing the peptide in solution form is also a bit risky because they are more prone to degradation. This solution has no antimicrobial agents. These Terms constitute the entire agreement between Buckle LLC and you in relation to your use of this Website, and supersede all prior agreements and understandings. This website is using a security service to protect itself from online attacks. Buckle LLC is permitted to revise these Terms at any time as it sees fit, and by using this Website you are expected to review these Terms on a regular basis. Both are suitable for subcutaneous intravenous, intramuscular, and intradermal injections. PDF SOLU-MEDROL (methylprednisolone sodium succinate for injection, USP The What is bacteriostatic water? Buy Bacteriostatic Water from our #1 recommended vendor Disclaimer: Peptides.org contains information about products that are intended for laboratory and research use only, unless otherwise explicitly stated. First, lets break down the basics of sterile water. The Buckle LLC is allowed to assign, transfer, and subcontract its rights and/or obligations under these Terms without any notification. Inspection Technical Guides, Recalls, Market Withdrawals and Safety Alerts, Inspections, Compliance, Enforcement, and Criminal Investigations. If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate countermeasures, and if possible, retrieve and save the remainder of the unused vehicle for examination. Any individual seeking any advice on any prescription medication, or any disease or condition, is advised to refrain from using this site and consult their healthcare provider. Provisions for sterilizing the inert gas or air supply lines. Sterilization procedures should parallel that of an autoclave and a typical system should include: Provisions for sterilizing the shelf support rods unless they are only exposed to the inside of the chamber after stoppering. Benzyl alcohol can be a topical irritant but in the concentration of 0.9% does not typically cause irritation and may provide some anesthetic effects. .063 mg/mL, 3200 mL c. 1000 mg/mL, 5 mL d. 64 mg/mL b. Its like a chemistry experiment, but instead of blowing things up, youll be improving your health. Another method of sterilization that has been practiced is the use of gaseous ethylene oxide. Medically reviewed by Drugs.com. Bacteriostatic 0.9% Sodium Chloride Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection. Once you open the seal of the sterile water vial, you will either have to use it preferably within the next 4 hours or discard it. Provisions for sterilizing and assuring the integrity of vent filters or filters used to sterilize the inert gas and air. It is essential to avoid repeated freeze-thaw cycles and exposure to light and high temperatures. They both are USP meaning they have an official monograph or documentation by the United States Pharmacopeia, both are not used for IV solutions. Both meet US Pharmacopeia (USP) standards. Adverse reactions are rare and can include fever, infection, and thrombosis. Peptide Reconstitution + Mixing Guide with Calculator, Read the full review on BPC 157 only at Muscle and Brawn, Limitless Life Nootropics (and Peptides) Review, Epitalon Peptide Guide: Benefits, Uses, Dosage, How to Safely Use SARMs to Sculpt Three-Dimensional Muscles and Torch Fat, The ONE Thing You MUST do Before starting SARMs if You Want to Keep Yourself Out of the Hospital, The MILDEST SARM that gives you gains without all the bloating, How to Properly Use SARMs to build 3D Muscles Without Experiencing Sloppy Noodle Syndrome. It could be potentially harmful to try to reconstitute a peptide meant for mixing with bacteriostatic water with sterile water. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Bacteriostatic waters preservative content prevents contamination for multiple doses, while sterile water may be contaminated after one use. Gather the following: alcohol swabs, bacteriostatic water, peptide powder, and a sterile syringe. Ob es sich um die Verwaltung von Kundeninvestitionen oder einen umfassenden Plan fr sie zu schaffen und ihre Familie sind unsere zertifizierten Planern gewidmet mit einem auergewhnlichen Service zu bieten. Patients, athletes, healthcare workers and others use sterile solutions to help in medication delivery, injections, irrigation and other uses. Bacteriostatic Water for Injection, USP must be made approximately isotonic prior to use. These formulations are less expensive to produce and more widely available than comparable products, such as sterile water [3]. The second step is to use your syringe and draw out 1ml of bacteriostatic water from the vial without really touching the needle as it could cause contamination. Muscle + Brawn is independent and reader-supported. Selective Estrogen Receptor Modulator (SERM), Induction of Ovulation with CLOMIMED 50 (Clomiphene Citrate), Anemia in Cancer Patients: treatment with DECAMED 250 (Nandrolone Decanoate), PROVIMED 25 (Mesterolone) for the Treatment of Male Infertility. The semi-rigid vial is fabricated from a specially formulated polyolefin. pose a threat of fluid overload except possibly in very small infants. Bacteriostatic Water (Bacteriostatic Water for Injection - RxList These Terms will be applied fully and affect to your use of this Website. This should hopefully shed some light on an easily confusing topic on which water to use. The primary uses of bacteriostatic water are as follows: When using bacteriostatic water for injections, certain precautions must be followed. Your Content must be your own and must not be invading any third-partys rights. See WARNINGS, PRECAUTIONS Reddit and its partners use cookies and similar technologies to provide you with a better experience. We strive to never have a piece of inaccurate information on this website. You are specifically restricted from all of the following. Plus, it is a great dilutant for a range of drugs and therapeutic substances, facilitating aqueous delivery without compromising potency or effectiveness. IMPORTANT - Use only Bacteriostatic Water for Injection with Benzyl Alcohol . Lysis is the breaking down of a cell or membrane. Bacteriostatic water is water with benzyl alcohol. However, you are not allowed to assign, transfer, or subcontract any of your rights and/or obligations under these Terms. Bacteriostatic 0.9% Sodium Chloride Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection. Once vials are partially stoppered, they are transported to the lyophilizer. Here are some general guidelines for storing reconstituted peptides: Short-term storage: If you plan to use the reconstituted peptide within a few days, you can store it at 4C in the dark. A mainstay in medical facilities, research labs, and beyond, bacteriostatic water resists contamination for up to 28 days after initial use. Use aseptic technique for single or multiple entry and withdrawal from all containers. I recommend using bacteriostatic water since that's what the peptide vendors sell and recommend. As the title suggestswhats the difference between bacteriostatic water and reconstitution solution? For those of you thinking about the volume of water, 1ml is usually enough for all the peptides available in the market. With our easy-to-use reconstitution calculator, you now dont have to worry about all the multiplication, division or the unit conversion and all. Note that you should absolutely not stir or shake the vial as it is going to damage the peptide and it will no longer be effective. Give half a minute for the alcohol to dry so that there is absolutely no risk of bacterial growth. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium. Due to the potential toxicity of benzyl alcohol in neonates, solutions containing benzyl alcohol must not be used in this patient population. For the reconstitution of HGH powder, bacteriostatic water is a great choice, as it preserves HGH solutions and efficiently dissolves lyophilized aggregates [16]. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. These Website Standard Terms and Conditions written on this webpage shall manage your use of this website. On the other hand, distilled water is rather more sterilized and contains neither organic nor organic materials. Parenteral drug products should be inspected visually for particulate matter Sorry Red, I was ambiguous with my 1st post. The small volume of fluid provided by Bacteriostatic Water for Injection, USP when used only as a pharmaceutic aid for diluting or dissolving drugs for parenteral injection, is unlikely to exert a significant effect on fluid balance except possibly in very small infants. SOLU-CORTEF Dosage and Administration (hydrocortisone sodium succinate Handlers should follow the applicable dosage and administration schedule [16]. The video I would recommend is embedded below. Mrose . Lets take a look at each one, where they differ, and where they overlap. The process of reconstitution is the same regardless of what kind of water you chose to reconstitute your AOD with. The very first step is pick the syringe size that you have purchased. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. It is also not known whether Bacteriostatic Water for Injection containing additives can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. did you ever get an answer? Benzyl alcohol, a preservative in Bacteriostatic Water for Injection, USP has been associated with toxicity in neonates. Home > Peptides > Peptide Reconstitution + Mixing Guide with Calculator. Bacteriostatic Water Vs. Sterile Water Bacteriostatic water and sterile water are essentially used for the same function which is to dissolve the drugs/medications for injecting purposes. How To Reconstitute PT-141 In Bacteriostatic Or Sterile Water Curious about Bacteriostatic Water for injections? Reddit and its partners use cookies and similar technologies to provide you with a better experience. These two solutions are sterile water and bacteriostatic water. If you are a peptide researcher or laboratory professional, you can safely enjoy the benefits of bacteriostatic water with proper use. Check a preview below or click on the image to see the full document. Once you have put the details, our reconstitution calculator will use its algorithm and devise the volume needed to get your peptides reconstituted! You cannot simply replace bacteriostatic water with sterile water and vice versa, as they are not the same thing. In case you have any issue diluting peptides in bacteriostatic water, you should add a small amount of 10% aqueous acetic acid for basic peptides and aqueous ammonia for acidic peptides. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. 94-101, 114; 1979. What is the difference between bacteriostatic water and sterile water We partner major pharmaceutical companies in India & abroad as a reliable and efficient contract manufacturer. Read more. Why is Water Essential to Reconstitution? Call your doctor for medical advice about side effects. It is only used for injections such as intravenous, intramuscular and subcutaneous. One would be used to control and record temperatures of the cycle as with sterilizers, and the other would be in the cold spot of the chamber. Sterile water is free of any organic materials but contains inorganic materials to some extent. However, this method requires special equipment and expertise. You use AA, wich is a .6% solution of acetic acid. If an adverse reaction does occur, discontinue the infusion, evaluate . Your IP: This significantly reduces the risk of infection [, It is an efficient solvent and presents minimal interaction with most medications [, Apart from medications, bacteriostatic water is also indicated for the reconstitution and injection of therapeutic research peptides and hormones [, Suitable injection routes are determined by the type of solute, the recipients needs, and target rates of diffusion and metabolization. Due to the lack of antimicrobials, sterile water can easily be contaminated once exposed to surroundings and even yourself. Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) of benzyl alcohol added as a bacteriostatic preservative. Reconstitution Definition: 569 Samples | Law Insider Purchase your full kit today to safely use bacteriostatic water for injections. He is responsible for ensuring the quality of the information presented on our website. Both bacteriostatic water and sterile water are not used for straight injections, they have to be diluted with a drug or solvent. In summary, the best way to store reconstituted peptides depends on the duration of storage and the desired shelf life. Water for Injection, USP is chemically designated H2O. Because it is vulnerable to contamination, it is sold in single-dose containers [5]. Step 1: Wash your hands and gather your materials. Wipe down all materials with an alcohol swab. Bacteriostatic Water for Peptides | Learn How to Prepare Bacteriostatic There are no adverse or bad side effects of using sterile water in small doses, one should never take it intravenously. Although adverse reactions to intravenous, intramuscular or subcutaneous injection of 0.9% benzyl alcohol are not known to occur in man, experimental studies of small volume parenteral preparations containing 0.9% benzyl alcohol in several species of animals have indicated that an estimated intravenous dose up to 30 mL may be safely given to an adult without toxic effects. Although, a small percentage of people report inflammation at the injection site if sterile water is used to dilute peptides that are to be injected intramuscularly. Before digging deeper into precise conditions required to store peptides, you should know that keeping a peptide vial away from intense light, high temperature and moisture is a MUST. See PRECAUTIONS. Daptomycin: a comparison of two intravenous formulations Do not use unless the solution is clear and seal intact. You will learn its various applications, how it differs from sterile water, and your best online source to buy bacteriostatic water kits. Obviously, a low fill would represent a subpotency in the vial. corrective measures. You may be surprised to learn that they are not interchangeable [5]. No, you cant just inject bacteriostatic water alone! To the extent that Peptides.org references a product that is also a prescription medication, Peptides.org does not does not offer medical diagnosis or treatment advice. On the other hand, if the peptide vial has been reconstituted, make sure that you store it between 2 and 8 degrees celsius because the reconstituted peptides are susceptible to minor temperature changes. Reconstitution means a process that may be used to initiate a range of accountability actions to . ], Hospira, Inc., Lake Forest, IL 60045 USA. This parenteral preparation is unlikely to pose a threat of fluid overload except possibly in very small infants. The universal rule is to use 1 milliliter of bacteriostatic water for every peptide that you reconstitute. Sample 1 Sample 2 Sample 3. Once you have received the verification code, you will be able to choose a new password for your account. Example would be 5g of CJC-1295 and 5g of ipamorelin. 11, pp. Correctly reconstituting peptides is essential in their effectiveness. Withdraw approximately 1mL of bacteriostatic water from the vial and slowly transfer it into the peptide container. Now here comes the crux of the article after talking about some of the major prerequisites of the peptide reconstitution process. ; New York City, Nov. 13, 1968. Also, nothing contained on this Website shall be interpreted as advising you. [See USP Controlled Room Temperature. Performance & security by Cloudflare. Often available as a lyophilized powder, hCG is best reconstituted with bacteriostatic water for injection due to the solvents efficiency and preservative agents. Peptide Reconstitution + Mixing Guide With Calculator - Muscle and Brawn Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation. Now that you know the general peptide reconstitution guidelines, lets talk about some of the exceptions. Lets nail the major differences right from the start. 1) Determine the quantity of peptide, in micrograms (mcg), in your vial. Sterile water usually comes in single-unit doses and the reuse of units is prohibited. Reconstitution Definition & Meaning | Merriam-Webster Medical Average normal adult daily requirement ranges from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production). We do the complete research and follow standards before starting the manufacturing process. The contents of Peptides.org are intended exclusively for qualified researchers. In closing, bacteriostatic water is often the preferred choice for injections in a range of contexts. Yes, distilled water can also be used to reconstitute peptides alongside the bacteriostatic and sterile water. Also, if you are experimenting with new peptides, it is always best to use bacteriostatic water to dilute the peptides. 1996-2023 RxList, Inc. An Internet Brands company. Nothing really. Typical finished product testing that should be reviewed includes dose uniformity testing, sterility testing, and any required stability testing of aged batches of reconstituted solutions. Management of Drug Shortages with 0.9% Sodium Chloride, Sterile Water In a nutshell, in order to make the 1 proper dosage of BPC-157, you would need to draw 10 units of water and then mix it by following the reconstitution guidelines. Helpful. But, for long-term storage of the powder form, the required temperature is less than -20 degrees celsius. On the other hand, TB-500, another potential peptide for quick healing is usually dosed at 7.66mg per week. Reconstitution follows the above method. Bacteriostatic water (BW) has a pH of about 5.7. If I have a 2mg bottle how much water total do I put into the vial? This Website is provided as is, with all faults, and Buckle LLC express no representations or warranties, of any kind related to this Website or the materials contained on this Website. They can manage our circadian rhythms, regulate growth hormones, help with weight loss, and even make us look younger. You should never inject bacteriostatic water without mixing in any medications because the benzyl alcohol in it causes the red blood cell lysis. Differences Between Bacteriostatic Water vs. Sterile Water Most peptide packages contain mixing instruction. Data sources include IBM Watson Micromedex (updated 1 May 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Report. Composed of sterile water and 0.9% benzyl alcohol and an organic preservative agent, bacteriostatic water resists bacterial growth and contamination [1]. Failure to do so risks the development of hemolysis, damaging the red blood cells [9, 10]. In these Website Standard Terms and Conditions, Your Content shall mean any audio, video text, images or other material you choose to display on this Website. Daptomycin RF has a longer in-use shelf period although times vary based on dosage form (vial, IV bag, or syringe) and diluent used. Due to the potential toxicity of benzyl alcohol in neonates, solutions containing benzyl alcohol must not be used in this patient population. Bacteriostatic Water vs. Sterile Water | Deus Medical Bacteriostatic water is commonly used for the injection of therapeutic compounds. There are only two kinds of water that are most safe to reconstitute peptides. If the product is reconstituted with Sterile Water for Injection, USP, use immediately and discard any unused portion. Obviously, the batching or compounding of these bulk solutions should be controlled in order to prevent any potential increase in microbiological levels that may occur up to the time that the bulk solutions are filtered (sterilized). ResearchPeptides.org follows the strictest sourcing guidelines in the health and nootropics industry. 51.222.156.250 Other than the content you own, under these Terms, Buckle LLC and/or its licensors own all the intellectual property rights and materials contained in this Website. Some of the important aspects of these operations include: the formulation of solutions; filling of vials and validation of the filling operation; sterilization and engineering aspects of the lyophilizer; and testing of the end product. Administration of an estimated 9 mL to a 6 kg infant or neonate is potentially capable of producing blood pressure changes. Peptide Dosing Guide. Reconstitution Solution versus Bacteriostatic Water. Because there is 1ml of bacteriostatic water, this means that we need to mix 5000mcg with 1ml of bacteriostatic water. The preservative agent (0.9% benzyl alcohol) in bacteriostatic water allows packaging in multi-dose vials that resist contamination for up to 28 days when used with sterile needles. For more information, please see our Recommended dosage guidelines are usually based on either the clinical trials or the efficacy of the peptide. The container can be re-entered multiple times (usually by a sterile needle) and the benzyl alcohol is added to ensure that bacteria does not grow in the water as diluting medications with tainted water can have some severe consequences. Specialists generally consider bacteriostatic water to be a more efficient solvent or dilutant. Peptide Reconstitution: Dosing, Mixing and Storage Guidelines Methylprednisolone sodium succinate has the same . Administration of an estimated 9 mL to a 6 kg infant or neonate is potentially capable of producing blood pressure changes. See additional information. Besides, to avoid the degradation of peptides from moisture, allow the reconstituted peptide vial to come at room temperature after pulling it out from the refrigerator. Immediately you can gauge which is appropriate based on allergies. Because they are antibiotics, low bioburden of these formulations would be expected at the time of batching. Injection of HGH is considered safe when prescribed by a doctor. But not all peptides dissolve in water easily, so it usually is recommended that you try to dissolve the peptide in any of these waters using Sonication. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Is Bacteriostatic Water The Same As Sterile Water? Remove Advertising. Bacteriostatic Water for Injection, USP containing additives should be given to a pregnant woman only if clearly needed. ; "Manufacturing Economies and Product Improvement Through Advanced Freeze Drying Techniques"; Reprint of talk to Annual Meeting of Parenteral Drug Assn. Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection, USP containing additives should be given to a pregnant woman only if clearly needed. Bacteriostatic water has a 0.9% benzyl alcohol content and an average pH level of 5.7, while sterile water is free of additives with a pH level of 5.0-7.0.