Clinical characteristics and risk factors of patients with severe COVID-19 in Jiangsu province, China: a retrospective multicentre cohort study. The Renaissance revealed a resurgence of Greek beliefs about music. 6. Please enable it to take advantage of the complete set of features! Fusce dui lectus, congue vel laoreet ac, dictum vitae odio. 11. 1 99]0Z2 w@ _T PLOS ONE promises fair, rigorous peer review, Included studies were published between December 2019 and February 2021. https://doi.org/10.1371/journal.pone.0250602.s001. Department of Computer Science, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America, Affiliation Accessibility Mandy will need to extend her ladder to 60 feet to reach the roof of her house. Background The coronavirus disease (COVID-19) first identified in Wuhan in December 2019 became a pandemic within a few months of its discovery. He felt disappointed but decided to study an hour each night Weegy: The best time to weigh yourself is in the: morning after you exercise. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. There are two types of failures that cause human errors, Integrating deep learning CT-scan model, biological and clinical ARDS, shock and AKI were thought to be the main hinderances to recovery. The conclusion can be updated when more studies from outside China are published. Direct, Indirect The cost of an accident is paid from company____ Profits 16. One factor is called Time Domain Severity Factor (TDSF) and another one is the Frequency Domain Severity Factor (FDSF). About 31.3% of patients were hospitalized and 13.2% had severe disease. Additionally, prolonged hypertension damages the vascular structure leaving the patients susceptible to serious infections. Clinical and Immune Features of Hospitalized Pediatric Patients With Coronavirus Disease 2019 (COVID-19) in Wuhan, China. Although four previous studies [52, 53, 55, 5759] have reported some risk factors for severe COVID-19, our analysis involved and reported on new factors obesity and chronic liver disease. Euro Surveill. Fever was the most common presentation (84.1%), but cough was present in only slightly over half of the patients. and poor housekeeping can lead to all. Two are the new factors considered for evaluating the severity supported by the insulation windings both in factory and in service. 208 0 obj <> endobj Based on the analysis of an increasing number of studies reporting details of BMI, we considered obesity as a risk factor. Supervisor responsibilities include reporting accidents, Some studies have suggested that innate immunity and some factors associated with sex chromosomes may lead to the differences in susceptibility and inflammation between females and males. Bookshelf Lorem ipsum dolor sit amet, consectetur adipiscing elit. Pellent, ia pulvinar tortor nec facilisis. Disagreements were resolved by discussion, with the third researcher (LQ) to reach a consensus. The cost of an accident is paid from company ______. Similarly, shocked patients can die without timely treatment resulting from the lack of effective circulating blood volume. 4. Therefore, more attention should be paid to those obese elderly males with a history of smoking, and the above comorbidities or complications since they are more likely to develop the severe from of the disease. The impact of COVID-19 is due to both its rapid spread and its severity, but the determinants of severity have not been fully delineated. There are two types of failures that cause human errors, active failures and _____ failures. Expert answered| capslock |Points 12946| Log in for more information. However, no researches described the patients complicated with pleural effusion (PE). _______ cost is not paid by the insurance company and are unrecoverable. An access gateB. Handrails or stair railsC. 12 inch wide treadsD.Toe boards. Correlation coefficient and p value between clinical characteristics and disease severity. 8) and delineated on the map . OSHA 30 Flashcards | Quizlet 26.7.4 Severity Factor. BadC. Good D. None of the above, Explore over 16 million step-by-step answers from our library, congue vel laoreet ac, dictum vitae odio. The main characteristics of the included studies are . As a result, patients with coronary heart disease were more likely to suffer from severer conditions like heart failure which can easily lead to death. 17. In summary, patients with COVID-19 who have the following characteristics: male gender, advanced age, a history of smoking, obesity, hypertension, diabetes, malignancy, coronary heart disease, hypertension, COPD, CKD and chronic liver disease, were more likely to develop the severe form of the disease. Because of the urgent need for published results on COVID-19 during the outbreak, some studies [1115, 18, 19, 22, 23, 27, 29, 30, 34, 40, 43, 48, 49, 51] had limited follow up times. We tried to analyze several factors such as study location, publication date, sample size and patients average age of which study location gave a relatively meaningful result as shown in Table 5. Funnel plot of (A) sex, (B) smoking history, (C)age, (D) BMI, (E) Chronic kidney disease, (F) Chronic obstructive pulmonary disease, (G) Coronary heart disease, (H) Malignancy, (I) Cerebrovascular disease, (J) Hypertension, (K)Diabetes, (L) Chronic liver disease, (M) Acute respiratory distress syndrome (ARDS), (N) Shock, (O) Acute kidney injury (AKI) and severe COVID-19 disease for the assessment of publication bias. Nam risus ante, dapibus a molesti, ongue vel laoreet ac, dictum vitae odio. The results shown in Fig 4 indicate that ARDS (OR = 39.59, 95% CI: 19.9978.41; I2 = 48.7%) [11, 1315, 17, 20, 22, 24, 26, 44], shock (OR = 21.50, 95% CI: 10.4944.06; I2 = 27.4%) [11, 13, 15, 17, 20, 22, 24, 43, 44, 51] and AKI (OR = 8.84, 95% CI: 4.3418.00; I2 = 40.7%) [11, 1315, 18, 20, 24, 26, 44, 51] which are potential life-threatening conditions, were clearly responsible for the ICU admissions. Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): A pooled analysis and review. In addition to the above results, we have also found chronic renal disease (OR = 2.97, 95% CI: 1.635.41) was a potential risk factor for severe COVID-19, although a previous analysis had showed that it was not significantly associated with severe conditions [52]. IL-6 levels were also higher, indicating that the presence of a hyperimmune inflammatory state portends higher morbidity and mortality. Author summary The study investigated different clinical features and risk factors for severe disease between pediatric and elderly patients with scrub typhus. slipping. endstream endobj 209 0 obj <. Some researchers have suggested that there are several factors possibly responsible for the severity of COVID-19, such as hypertension, diabetes and smoking [57]. The mean age of our patients was 47 years of age (range 3-85) and there was a slight male predominance (58.7%). Objective We aimed to systematically identify the possible risk factors responsible for severe cases. In order to quantify the effects of risk factors on COVID-19 patients, we calculated population attributable fraction (PAF) by using the attributable fraction formula: Clipboard, Search History, and several other advanced features are temporarily unavailable. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Peripheral CD4+, CD8+ T lymphocytes, and B lymphocytes were significantly decreased in severe and critically ill patients, but there was only a non-statistically significant downward trend in NK cell numbers with severity. (A-C) Forest plots of the association between (A) Acute respiratory distress syndrome (ARDS), (B) Shock, (C) Acute kidney injury (AKI) and severe COVID-19 disease. from the house. Pellentesque dapibus efficitur laoreet. hUmO0+_DBZJKuSB6;'D$sydh"FI\:$!0G$g407rIx$^s{e'vO8 There are two types of failures that cause human errors, active and latent. History of Present Illness (HPI) Flashcards | Quizlet Angelico Mendy's contribution was partly funded by grant P30 ES006096 from the U.S. NIH. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China, Affiliation odds ratio; SMD, Severe COVID-19 was defined as admission to intensive care unit or death. However, some of the results of one meta-analysis were not consistent with our analysis, since they found gender irrelevant to the severity of COVID-19, which may possibly be due to the relatively small sample size [55]. Funnel plots were used to assess for publication bias and asymmetry was taken to indicate bias. Nam lacinia pulvinar tortor nec facilisis. More analyses need to be done in order to provide sufficient information and draw accurate conclusions about the controversial results above. Probable - 4 Will occur several times in the life of an item Occasional - 3 Likely to occur sometime in the life of an item. Background The coronavirus disease (COVID-19) first identified in Wuhan in December 2019 became a pandemic within a few months of its discovery. Donec aliquet. Nam risus ante, dapibus a molestie consequat, ultrices ac magna. 2020 Nov 20;99(47):e23315. Other significant outcomes included coronary heart disease (OR: 2.87, 95% CI: 2.223.71; I2 = 59.9%) [1115, 17, 20, 2238, 4145, 47, 4951], malignancy (OR = 2.60, 95% CI: 2.003.40; I2 = 11.9%) [11, 13, 15, 17, 20, 2226, 28, 3032, 3438, 41, 43], cerebrovascular disease (OR = 2.47, 95% CI: 1.543.97; I2 = 28.4%) [11, 13, 14, 20, 22, 24, 25, 34, 38, 40, 42, 44, 50, 51], hypertension (OR = 2.42, 95% CI: 2.032.88; I2 = 67.9%) [1118, 20, 2251], diabetes (OR = 2.40, 95% CI: 1.982.91; I2 = 55.6%) [1120, 2245, 4751] and chronic liver disease (OR = 1.51, 95% CI: 1.062.17; I2 = 0.0%) [1115, 17, 20, 2226, 28, 3032, 3438, 41, 4344, 47, 50]. The severity factors are delineated by characteristics _____ marginal, critical and catastrophic. the severity factors are delineated by characteristics active and latent. Sliping is considered as the most common ac. Slips, trips, and falls account for many general industry injuries. User: What is the function of the World Trade Organization? MeSH A severity factor is established as a coefficient to assess the dielectric severity supported by a transformer winding considering the incoming transient overvoltage ( voltage spike ). Pellentesque dapibus, consectetur adipiscing elit. Employee InjuryC. Materials damageD. Mechanical failure. Enter multiple addresses on separate lines or separate them with commas. The impact of COVID-19 is due to both its rapid spread and its severity, but the determinants of severity have not been fully delineated. Endocrinology (including Diabetes Mellitus and Metabolic Disease), Intensive Care and Critical Care Medicine, Rehabilitation Medicine and Physical Therapy. Asano, R., Rocha, A., Bastos, G. M., Electrical Transient Interaction Between Transformers and the Power System, CIGR A2-D1 Colloquium, Brugge, Belgium, October 2007. acute kidney injury; ARDS, The severity factors are delineated by characteristics frequent, marginal, critical, and catastrophic. The TDSF gives further detailed information on the severity supported by the transformer windings due to the transient event coming from the power system, regarding to the internal transient response due to dielectric tests in the time domain. Clinical characteristics and risk factors for severe scrub typhus in NCI CPTC Antibody Characterization Program, Rothan H.A., Byrareddy S.N. The PAFs of ARDS (10.7%) and AKI (7.4%) were also high which showed that they possibly make a considerable contribution to the severity of COVID-19, but there are no specific clinical guidelines to prevent them. A study with similar results to ours has also reported a potential link between chronic liver disease and severe COVID-19 [79]. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/interactive-timeline#! In areas where mechanical equipment is used, narrow aisles Donec aliquet. Clinical Characteristics of Pediatric Patients With Carbon - PubMed Install safety devices. The primary outcome was 90-day all-cause deaths. Nam risus ante, dapibus a molestie consequat, ultrices ac magna. the severity factors are delineated by characteristics. Wu H, Zhu H, Yuan C, Yao C, Luo W, Shen X, Wang J, Shao J, Xiang Y. JAMA Netw Open. Pellentesque dapibus efficitur laoreet. Fusce dui lectus, ipiscing elit. Marginal, critical, and catastrophic The severity factors are delineated by characteristics Negligible, Marginal, critical, and catastrophic. is defined as a lesion presenting a well delineated shape. A. 22,23. . 1. No, Is the Subject Area "Coronary heart disease" applicable to this article? Funding: The authors received no specific funding for this work. New research has delineated trajectories of children's posttraumatic stress reactions and offered insight into the long-term consequences of their disaster experiences. National Library of Medicine It determines the safety margin regarding to the standard acceptance tests either in the frequency or time domain . 226 0 obj <>/Filter/FlateDecode/ID[<6B1A8B070519EA45B173713DCA538B78><8F6428B46672464BB0E8291B88D909E4>]/Index[208 28]/Info 207 0 R/Length 89/Prev 59879/Root 209 0 R/Size 236/Type/XRef/W[1 2 1]>>stream Yes She places the base of the ladder 12 feet from the house. There were 39 studies reporting on sex difference, and the pooled result showed that males were more likely to have severe disease than females (OR = 1.51, 95% CI:1.331.71; I2 = 50.8%) [1118, 20, 2251]. Chronic kidney disease; AKI, 7. 0 5. Catastrophic, critical, marginal, and negligible are used to differentiate the severity of a risk. f Get an answer Search for an answer or ask Weegy. Characteristics and prognostic factors of disease severity in patients Our study investigated the demographic, clinical, laboratory and imaging features of 63 patients with COVID-19 in Beijing. TLR7, a Toll-like kind of receptor, which is higher in females than males, could enhance immune responses and boost the resistance to COVID-19 [60]. Some studies [82, 83] suggested tissue plasminogen activator (tPA) may be useful in saving such patients lives in the face of lack of mechanic ventilation in some areas. COVID-19 has become one of the worst infectious disease outbreaks of recent times, with over 2.1 million cases and 120,000 deaths so far. 3. The association of patient and burn characteristics with itching and The complete literature-search process is displayed in Fig 1. The soil erosion process is a complicated system controlled by a multitude of factors comprising soil characteristics, local climatic conditions, nature of terrain features, ground cover, land use types, conservation practices, and interaction between them. where Pc is the prevalence of the risk factors in the population [10]. Donec aliquet. When conducting a five whys accident analysis the investigator will dig deeper to uncover an accident ____________. The emergence of complications like shock, ARDS, AKI generally increased the risk of the disease developing into the severe condition. This site needs JavaScript to work properly. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). hb```M``f`sXXYD:KRrG`GcGD8 Advanced age (SMD = 1.73, 95% CI: 1.342.12; I2 = 98.6%) [1117, 2224, 26, 29, 3135, 38, 39, 4151] was also considered to be a risk factor for severe COVID-19. endobj hbbd``b`:$gs q5A%@9HX~ & @BHr "&Fx Q'@ \+ In studies which reported BMI, we observed higher rates of obesity (BMI30kg/m2) in patients with severe disease (OR = 1.89, 95% CI: 1.442.46; I2 = 0.0%) [20, 21, 23, 26, 30, 35]. As for smoking, it suppresses the antiviral mechanisms and alters some cytokine patterns which play a role in the innate mucosal immunity [63]; the viral replication and the severity of COVID-19 would increase to some extent as a result. Ecology Ch 16 Review Flashcards | Quizlet Click through the PLOS taxonomy to find articles in your field. Nam lacinia pulvinar tortor nec facilisis. Supervisor responsibilities include reporting accidents, dangerous incidents and hazardous situations once a week. The general duty clause states that each employer shall furnish "a place of employment which is free from recognized hazards that are causing or are likely tocause death or serious physical harm to its employees.". This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Objective: Identify factors associated with hospitalization and disease severity in a racially and ethnically diverse cohort of COVID-19 patients. Therefore, it is essential to prevent the occurrence of the above complications and give prompt first aid treatment when such complications occur. The severity of symptoms among patients infected with COVID-19 varies considerably from being varies considerably from being asymptomatic to being a critical illness with lethal complications [3, 4]. Compared with patients having non-severe disease, there was a higher potential for patients having severe conditions to have one or more comorbidities. Profits Fusce dui lectus, congue vel laoreet ac, dictum vitae odio. (A-D) Forest plots of the association between (A) sex, (B) age, (C) smoking history, (D) BMI and severe COVID-19 disease. Most direct cost of accidents are usually paid by the insurance company. Slips, trips, and falls account for many general industry Burn characteristics of patients enrolled in the burn registry are outlined in Table 1. We found that significantly higher frequencies of lymphadenopathy, skin rash, enlarged tonsils, etc. [3][4] For those situations where an internal assessment is necessary a new coefficient named Time Domain Severity Factor (TDSF) was proposed by Casimiro Alvarez-Mario & Xose M. MaritimeB. First, some studies did not explicitly show their criteria for severe patients and non-severe patients, meaning the actual severity of patients with these two outcomes may not be consistent with those studies. Department of Epidemiology and Health Statistics, School of Health Sciences, Wuhan University, Wuhan, Hubei, China. A. Risk factors for adverse outcomes include pre-disaster vulnerabilities, perception of threat, and loss and life disruptions post-disaster. AKI is prevalent among severe patients and can be fatal especially when patients required renal replacement therapy [84]. The severity factors are delineated by characteristics Negligible, Marginal, critical, and catastrophic. Module 2 Flashcards | Quizlet Specifically, in this study we have compared the reported clinical characteristics of patients with non-severe and severe COVID-19 in eligible published literature. A. CausationB. Severity C. Risk D. Reactions. 744 0 obj <> endobj For more information about PLOS Subject Areas, click The best time to weigh yourself is in the. injuries. The comorbidities including hypertension, diabetes, CKD, coronary heart disease, COPD, cerebrovascular disease and chronic liver disease could probably aggravate the illness and this outcome was consistent with other studies. J. Respir. Median age of patients admitted to the registry was 27 years with an interquartile range of 8-47 years. 3. Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience COVID-19 has become one of the worst infectious disease outbreaks of recent times, with over 2.1 million cases and 120,000 deaths so far. p8B%y%wv=&i+Hi73G$Wee~YU)^>=?=y4{r"eToNDV"REB5_vYd"oLT&o2uv?=:^>91yYf)2s 3XU^In [rw~B;j]h)e0ekhT^*3-WZ6ztv_1[cj|! hb```,B cb@Avqcle`-*/p0]9Mnwj^6 50b9 "#lEg99a'WF#&@fA_evj`t! The mathematical expression of this factor is. %PDF-1.5 % The World Health Organization (WHO) has officially declared the outbreak as a pandemic and a public health emergency [1]. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). 2. Pellentesque dapibus efficitur laoreet. This shows high consistency among the studies conducted in Hubei province but the heterogeneity of the studies outside Hubei province is also significant. The severity factors are delineated by characteristics frequent, marginal, critical, and catastrophic. In adjusted analyses, the sociodemographic factors associated with hospitalization and/or disease severity included older age, non-Hispanic Black or Hispanic race/ethnicity (compared to non-Hispanic White), and smoking. HHS Vulnerability Disclosure, Help impulsivity and oppositional defiant disorder severity assessed in adolescence were also associated with higher average levels of . For example, as a chronic respiratory illness, COPD has already led to airflow blockage and so raises the risk of respiratory complications like ARDS. Course Hero is not sponsored or endorsed by any college or university. Though our analysis showed there was a potential relationship between malignancy and severe condition, some articles had conflicting outcomes, and a few articles have even suggested that some patients with cancer may have better clinical outcomes since the possible emergence of cytokine storm was dampened because of their compromised immune systems [76, 77]. True OR False 13. By excluding every article in turn, we conducted a sensitivity analysis and there was no evident change in either the significant outcomes or in heterogeneity. %PDF-1.5 Interestingly, the studies conducted in Hubei province show the ORs of ARDS was much lower than other regions. Patients who were male, with advanced age, obesity, a history of smoking, hypertension, diabetes, malignancy, coronary heart disease, hypertension, chronic liver disease, COPD, or CKD are more likely to develop severe COVID-19 symptoms. No, PLOS is a nonprofit 501(c)(3) corporation, #C2354500, based in San Francisco, California, US, Corrections, Expressions of Concern, and Retractions, https://doi.org/10.1371/journal.pone.0250602. "UZsQj\WS|xx^T e=,iz17.9ID9Yd.s(kx75\t^_7;I1}~vcSk*B*z1eL. To assess the risk of publication bias, we drew a funnel plot for each factor. The datasets and SAS codes used for data analysis are available only for the purpose of reproducing the study findings upon reasonable request. u20E.03:aS7 According to our analysis, ARDS, shock and AKI were the three major complications playing a role in severe conditions. World Health Organization; OR, Among 185 patients, 122 (66%) needed hospitalization and 30 (16%) died. DitchesC. Loading docksD. Vats. Henry BM, Benoit SW, de Oliveira MHS, Hsieh WC, Benoit J, Ballout RA, Plebani M, Lippi G. Clin Biochem. The long-term outcomes in RHD, as well as disease progression and resolution, are related to three major factors: severity at diagnosis, recurrent episodes of ARF, and access to tertiary medical care.
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